Powering the future of IVF intelligence

AI decision support for
sperm selection in IVF

AI decision support for sperm selection in IVF

BetterFit’s real-time AI analyzes 50+ morphometric parameters invisible to the human eye, bringing predictable,
consistent decision support to sperm selection at the moment of ICSI.

BetterFit’s real-time AI analyzes 50+ morphometric parameters invisible to the human eye, bringing predictable, consistent decision support to sperm selection at the moment of ICSI.

Global IVF market · 8% CAGR

$30B

IVF cycles performed annually

4M+

Oocytes injected each year

40-60M

BetterFit total addressable market

$1B+

The heartbreaking reality

IVF success is still painfully unpredictable

For decades, reproductive medicine has been limited by inconsistent outcomes. Behind every failed cycle is a couple who invested their savings, time and hope, only to face heartbreak.

~50%

of IVF couples never take home a baby.

55-60%

of cycles fail to result in a live birth.

$18-25k

cost per cycle in the US, out-of-pocket.

60-70%

of women require 2 or more retrieval cycles.

30% of IVF patients retrieve ≤ 5 oocytes. When every oocyte is precious, every fertilization counts.

30% of IVF patients retrieve ≤ 5 oocytes. When every oocyte is precious, every fertilization counts.

The IVF “Black box”

The bottleneck is manual sperm selection

80% of IVF procedures use ICSI, yet the single most consequential step still depends on a technician’s eye.

Step 1

Oocyte
retrieval

The bottleneck

Sperm
selection

Step 3

Fertilization
(ICSI)

Step 4

Embryo
development

Step 5

Birth
80% of procedures use ICSI

Manual injection is now the global standard of care.

Selection is subjective

It remains manual and entirely technician-dependent.

Result: 65-75% fertilization

Global fertilization rates have been stuck for decades.

80% of procedures use ICSI

Manual injection is now the global standard of care.

Selection is subjective

It remains manual and entirely technician-dependent.

Result: 65-75% fertilization

Global fertilization rates have been stuck for decades.

The problem

35 years of stagnation in
fertilization rate (65–75%)

Today, sperm selection is subjective and manual, with no established guidelines.

90% 70% 50% 1991 2005 2020 2026 BetterFit Mean Fertilization Rate (%) Year 1991–2026: no change in fertilization rate ~65–75% 85–87% BetterFit breakthrough Increasing fertilization results in more EMBRYOS more LIVE-BIRTHS

The solution

Replacing human variability with AI predictability and Precision

BetterFit empowers embryologists. It does not replace them. Our AI scores every candidate sperm
against parameters no microscope eye can resolve.

Manual selection

65-75% fertilization rate

Subjective, eye-based interpretation

Inconsistent, operator-dependent outcomes

No record linking selection to results

BetterFit AI

~85-87% predicted fertilization rate

Analyzes 50+ morphometric parameters

Consistent, reproducible recommendations

Every procedure enriches the data moat

How it works

Real-time decision support
in the moment of ICSI

Not automation. The embryologist always remains in control.

Advanced computer vision

Evaluates high-resolution sperm imagery instantly.

Zero workflow disruption

Off-the-shelf optical configuration compatible with standard IVF microscopes.

Standardized outcomes

Eliminates operator variability across different technicians and lab locations.

We empower embryologists. We do not replace them.

Seamless lab integration

Non-invasive. Plug-and-play.
No workflow disruption.

BetterFit is decision support that works with the microscopes your lab already owns.

Select

1

The embryologist picks a candidate sperm at the moment of ICSI.

Image

2

A high-resolution camera captures the sperm image.

Analyze

3

The image is uploaded to the BetterFit cloud and scored in real time.

Decide

4

The AI returns a clear Green / Red recommendation to guide the call.

Clinical proof

85-87% prediction accuracy in our proof-of-concept

Validated in fresh ICSI cycles at Elisha Hospital, Israel, dramatically outperforming the human baseline.

Sperm images analyzed in the
Proof-of-Concept study.

412

Fertilization-positive vs. negative, from a
balanced, outcome-labelled dataset.

324 / 88

Patient age range, proven fertility,
MII oocytes, fresh ICSI cycles.

18-37

Proof-of-Concept conducted at
Elisha Hospital, Israel.

Elisha

Why it matters

Higher fertilization rate

more births

Published evidence shows fertilization rate is a direct lever on cumulative live-birth rate. Published studies suggest that higher fertilization rates are associated with improved cumulative live-birth outcomes.

20.1%

41.3%

< 65%

fertilization

> 80%

fertilization

Cumulative live-birth rate by fertilization band · Scaravelli et al., Fertil Steril 2021

The economics

Impact of a 10% increase in fertilization

Measurable ROI across patients, clinics and BetterFit alike.

For patient

Higher success, lower cost

$20k+

potential savings by avoiding redundant retrieval cycles

  • More embryos and a higher birth rate
  • Shorter time-to-pregnancy
  • Reduced patient agony and treatment dropout

For clinics

Revenue & reputation

$0.5-1M

added annual revenue for a ~1,000-cycle clinic

  • Higher success rates lift rankings and brand
  • More PGT-A and frozen embryo transfers
  • Fewer dropouts, shorter patient journeys

Growth strategy

A three-phase path to a $1B+ market

Immediate revenue today, a world-first capability tomorrow, and an unreplicable data asset underneath it all.

Phase 1 Now

Fertilization AI. Immediate Revenue.

Morphology-based sperm selection for ICSI with 85%+ fertilization prediction and immediate revenue potential.

Phase 2 Next

Gender & genetic screening. +$800m market

We are researching a potential, non-invasive capability to identify X vs. Y chromosomes and genetic-disease markers purely from optical morphology.

Phase 3 Moat

Sperm image dataset

The industry’s first high-resolution dataset linking sperm morphology to biological birth outcomes, impossible to replicate.

Our go-to-market moat

Direct reach into the global IVF community

Prof. Zeev Shoham’s network gives BetterFit a distribution channel that competitors cannot buy.

IVF professionals

Reachable list with 20-25% email engagement.

104k

Knowledge hub

The field’s central online center of knowledge.

IVF

Congress attendees

Bi-annual IVF congresses, each drawing 10,000+.

10k+

Leading textbook

Co-authored the authoritative ART textbook.

25 yrs

The team

Built by leaders in IVF and MedTech commercialization

Deep clinical authority, global IVF access and proven healthcare execution.

Prof. Zeev Shoham, MD

Prof. Zeev Shoham, MD

Co-founder & chief medical officer

  • Global IVF Key Opinion Leader
  • Founder of IVF-Worldwide (104,000 professionals)
  • Co-editor of leading IVF textbook
  • Former Head of IVF, Kaplan Medical Center
  • Organizer of leading international IVF congresses
Tsvi Bahat

Tsvi Bahat

Chief executive officer

  • 25 years in MedTech leadership
  • Multiple CEO roles across healthcare ventures
  • Executive VP of Sales in a NASDAQ-traded company (annual revenues $45M)
  • Scaled US revenues from zero to $10.5M in 24 months
  • Opened a direct US sales office and JVs in Asia and Europe
Moshe Flugelman, MD

Moshe Flugelman, MD

Co-founder & chief strategy officer

  • Physician entrepreneur and strategist
  • Professor of Medicine, Technion IIT
  • Extensive startup and innovation experience
  • Bridges clinical medicine and business execution
Dr. Elena Milner

Dr. Elena Milner

Senior embryologist

  • IVF Laboratory Director, Elisha Medical Center
  • Direct clinical workflow expertise
  • Oversees embryology integration and validation
  • Brings real-world IVF operational insight

Join us

Build the data & intelligence layer of IVF

Tell us a little about you and the question you have, and we will get back to you personally.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.
I'm interested in*